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Excipients per 0.5 mL
Albumin, Human
MMR II (Merck)
MMR
0.3 mg
Attenuvax (Merck)
Measles
0.3 mg
Mumpsvax (Merck)
Mumps
0.3 mg
Meruvax II (Merck)
Rubella
0.3 mg
ProQuad (Merck)
MMR+Varicella
0.31 mg
RabAvert (Novartis)
Rabies
<0.3 mg
Albumin, Egg
Afluvia (CSL)
Influenza
≤1 mcg Agriful (Novartis) Influenza residual, <0.4 mcg
Fluarix (GSK)
Influenza
≤0.1 mcg
FluLaval (GSK)
Influenza
≤1 mcg
Fluvirin (Novartis) Influenza residual Fluzone (sp) Influenza residual H1N1 (GSK) H1N1 Influenza ≤1 mcg H1N1 (CSL) H1N1 Influenza ≤1 mcg H1N1 (Novartis) H1N1 Influenza ≤1 mcg Albumin, Bovine
Havrix (GSK)
Hep A
<1 mg/mL (<0.5 mg)
Pentacel DTaP-IPV-Hib 3.3 mg
Vaqta (Merck)
Hep A
Amino Acids
Cervarix (GSK)
HPV in media
Comvax (Merck) Hib-HepB in media Gardasil (Merck) HPV in media
Havrix (GSK)
Hep A
in media, 0.3%w/v
HibTITER (Wyeth)
Hib
in media
Menveo (Novartis)
Meningococcal
"...CY medium containing ... amino acids."
Twinrix (SKB)
Hep AB
Vivotif Berna (Berna)
Typhoid
1.4-7 mg
Ammonium Sulfate
ActHIB (sp)
Hib
HibTITER (Wyeth)
Hib
OmniHIB (sp)
Hib
Arginine
Fluzone (sp)
Influenza
2.42 mg
FluMist (Medimmune) Influenza 2.42 mg/dose H1N1 Intranasal (Medimmune) H1N1Influenza 2.42 mg/dose Ascorbic acid
Vivotif Berna (Berna)
Typhoid
1-5 mg
Calcium Chloride
Afluvia (CSL)
Influenza
1.5 mcg H1N1 (CSL) H1N1 Influenza 1.5 mcg DNA
ProQuad (Merck)
MMR+Varicella
residual
Vaqta (Merck)
Hep A
<4x10-6 mcg
Varivax (Merck)
Varicella
residual
Zostavax (Merck)
Varicella Zoster
residual
Formaldehyde
Adacel (ap)
Tdap
≤5 mcg (0.005 mg)
Agriful (Nov)
Influenza
≤10 mcg
BioThrax (Bioport)
Anthrax
100 mcg/mL (0.1 mg)
Boostrix (GSK)
Tdap
≤100 mcg (0.1 mg)
Comvax
Hib-HepB
≤0.0004%
DAPTACEL (sp)
Td
≤5 mcg (0.1 mg)
DECAVAC (sp)
DTaP
≤100 mcg
DT (sp)
DT
≤0.02%
Fluarix (GSK)
Influenza
≤50 mcg
FluLaval (GSK)
Influenza
≤25 mcg
Fluzone (sp)
Influenza
≤100 mcg (0.1 mg)
H1N1 (sp)
H1N1 Influenza
≤100 mcg (0.1 mg)
H1N1 (GSK)
H1N1 Influenza
≤25 mcg (0.025 mg)
Infanrix (GSK)
DTaP
≤100 mcg (0.1 mg)
IPOL (sp)
IPV
≤0.02%
JE-Vax (sp)
Japanese Encephalitis
<100 mcg (0.1 mg)
Kinrix (GSK)
DTaP-IPV
<100 mcg (0.1 mg)
Menveo (Novartis)
Mening
Residual
Pediarix (GSK)
DTaP-HepB-IPV
≤100 mcg (0.1 mg)
Pentacel (sp)
DTaP-IPV-Hib
<5 mcg residual
Tetanus Toxoid Adsorbed (sp)
TT
≤0.02%
TriHIBit (sp)
DTaP-Hib
≤100 mcg (0.1 mg)
Tripedia (sp)
DTaP
≤100 mcg (0.1 mg)
Vaqta (Merck)
Hep A
<0.8 mcg (0.008 mg)
Formaline
Havrix (GSK)
HepA
≤0.1% mg/mL
Twinrix (GSK)
Hep AB
≤0.1 mg/mL
Gelatin (Bovine)
RabAvert (Novartis)
Rabies
<12 mg (Polygeline)
Attenuvax (Merck)
Measles
Hydrolyzed Gelatin, 14.5 mg
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Flumist (MedImmune) Influenza Hydrolyzed Gelatin, 2.00 mg Fluzone (sp)
Influenza
0.05% (added as a stabilizer)
H1N1 (sanofi pasteur)
H1N1 Influenza
0.05% (added as a stabilizer) H1N1-nasal (MedImmune)
H1N1 Influenza
Hydrolyzed Gelatin, 2.00 mg JE-Vax Japanese Encephalitis <500 mcg Meruvax II (Merck)
Rubella
Hydrolyzed Gelatin, 14.5 mg
MMR II (Merck)
Measles, Mumps, Rubella
Hydrolyzed Gelatin, 11 mg
Mumpsvax (Merck)
Mumps
Hydrolyzed Gelatin, 14.5 mg
ProQuad (Merck)
MMR+varicella
Hydrolyzed Gelatin, 14.5 mg
Tripedia (sp)
DTaP
residual used in the production of the pertussis concentrate
Varivax (Merck)
Varicella
Hydrolyzed Gelatin, 12.5 mg/dose
YF-Vax (sp)
Yellow Fever
as stabilizer
Zostavax (Merck)
Varicella Zoster
Hydrolyzed gelatin, 15.58 mg
Gentamicin sulfate
Flumist (Medimmune)
Influenza
<0.015 mcg/mL
Fluarix (GSK)
Influenza
≤0.15 mcg
H1N1-nasal (MedImmune) H1N1 Influenza ≤0.015 mcg/mL Glutaraldehyde
ADACEL (ap)
Tdap
<50 ng residual
Boostrix (GSK) Tdap trace
DAPTACEL (sp)
DTaP
<50 ng residual
Infanrix (GSK)
DTaP
trace
Kinrix (GSK)
DTaP-IPV
trace
Pentacel (sp)
DTaP-IPV-Hib
<50 ng residual
Pediarix (GSK)
DTaP-HepB-IPV
trace
Glycerin
Dryvax (Wyeth)
Smallpox
50% of diluent
Polyethylene glycol p-isooctylphenyl ether
Fluzone (sp)
Influenza
≤0.02%
H1N1 (CSL)
H1N1 Influenza
≤0.02%
Lactose
MENOMUNE-A/C/Y/W-135 (sp)
Mening
2.5-5.0 mg
Vivotif Berna (Berna)
Typhoid
100-180 mg
Magnesium stearate
Vivotif Berna (Berna)
Typhoid
3.6-4.4 mg
Monosodium glutamate
Flumist (Medimmune)
Influenza
0.188 mg/dose
H1N1-nasal (MedImmune) H1N1 Influenza 0.188 mg/dose
ProQuad (Merck)
MMR+Varicella
0.4 mg
Varivax (Merck)
Varicella
0.5 mg
Zostavax (Merck)
Varicella Zoster
0.62 mg
Neomycin
Afluria (CSL)
Influenza
≤0.2 pg (Neomycin sulfate)
Agriflu (Novartis)
Influenza
≤0.02 mcg
Attenuvax (Merck)
Measles
25 mcg
Dryvax (W)
Smallpox
100 mcg/mL (50 units/0.5 mL)
Fluvirin (Novartis)
Influenza
≤2.5 mcg
H1N1 (CSL)
H1N1 Influenza
≤0.2 pg (Neomycin sulfate)
H1N1 (Novartis)
H1N1 Influenza
≤2.5 mcg
Havrix (GSK)
Hep A
≤40 ng/mL (Neomycin sulfate)
Imovax Rabies (sp)
Rabies
<150 mcg (Neomycin Sulfate)
IPOL (sp)
Polio
<5 ng
Kinrix (GSK)
DTaP/IPV
≤0.05 ng
Meruvax II (Merck)
Rubella
25 mcg
MMR II (Merck)
MMR
25 mcg
Mumpsvax (Merck)
Mumps
25 mcg
Pediarix (GSK)
DTaP-HepB-IPV
≤0.05 ng
Pentacel (sp)
DTaP-IPV-Hib
<4 pg
ProQuad (Merck)
MMR+Varicella
<16 mcg
RabAvert (Chiron)
Rabies
< 1 mcg
Twinrix (GSK)
Hep AB
≤20 ng
Varivax (Merck)
Varicella
trace amounts
Zostavax (Merck)
Varicella Zoster
trace amounts
Phenol Red indicator Imovax Rabies (sp) Rabies <20 mg
Rotarix (GSK)
Rotavirus
Phosphate-buffered Isotonic Solution Afluria (CSL)
Influenza
Fluvirin (Novartis)
Influenza
≤1 mcg
FluLaval (GSK)
Influenza
Polymyxin B
Afluria (CSL)
Influenza
≤0.03pg
Dryvax (W)
Smallpox
100 units/mL (50 units/0.5 mL)
Fluvirin (Novartis)
Influenza
undetectable amounts
H1N1 (Novartis)
H1N1 Influenza
≤3.75 mcg
IPOL (sp)
Polio
25 ng
Kinrix (GSK)
DTaP/IPV
≤0.01 ng
Pediarix (GSK)
DTaP-HepB-IPV
≤0.01 ng
Pentacel (sp)
DTaP-IPV-Hib
<4 pg (polymyxin B sulfate)
2-phenoxyethanol
ADACEL (ap)
Tdap
3.3 mg (not used as a preservative)
Polydimethylsilozane-based antifoam agents
Typhim Vi (sp)
Typhoid
residual
Polygeline
RabAvert (Novartis)
Rabies
12 mg
Polysorbate 20
Havrix (SKB)
HepA
0.05 mg/mL
Twinrix (SKB)
Hep AB
Polysorbate 80
Agriflu
Influenza ≤50 mcg
Boostrix (GSK) Tdap ≤100 mcg
Fluarix (GSK)
Influenza
≤0.380 mg
Gardasil (Merck) HPV 50 mcg
Infanrix (GSK)
DTaP
≤100 mcg (0.1 mg)
JE-Vax (sp)
Japanese Encephalitis
0.007%
Kinrix (GSK)
DTaIPV
≤100 mcg
Pediarix (GSK)
DTaP-HepB-IPV
≤100 mcg
Pentacel DTaP-IPV-Hib 10 ppm
RotaTeq (Merck)
Rotavirus
TriHIBit (sp)
DTaP-Hib
Tripedia (sp)
DTaP
Potassium chloride Afluria (CSL)
Influenza
20 mcg
H1N1 (CSL)
H1N1 Influenza
20 mcg
ProQuad (Merck)
MMR+Varicella
60 mcg
Varivax (Merck)
Varicella
0.08 mg
Zostavax (Merck)
Varicella Zoster
0.10 mg
Potassium glutamate
RabAvert (Novartis)
Rabies
1 mg
Potassium phosphate
Afluria (CSL)
Influenza
20 mcg (monobasic)
FluMist (Medimmune)
Influenza
2.26 mg/dose (dibasic )
0.96 mg/dose (monbasic )
H1N1 (CSL)
H1N1 Influenza
20 mcg, monobasic
H1N1 Intranasal (Medimmune)
H1N1Influenza
2.26 mg/dose (dibasic )
0.96 mg/dose (monbasic )
ProQuad (Merck)
MMR+Varicella
72 mcg (monobasic)
36 mcg (dibasic)
Varivax (Merck)
Varicella
0.08 mg (monobasic)
Zostavax (Merck)
Varicella Zoster
0.10 mg (monobasic)
Protein
Cervarix (GSK)
HPV
may contain <40 ng viral protein and <150 ng bacterial cell protein
Havrix (GSK)
Hep A
≤5 mcg (MCR-5 Cellular)
HibTITER (Wyeth)
Hib
25 mcg CRM197 protein
Menveo (Novartis)
Mening
32.7-64.1 mcg CRM197 protein
ProQuad (Merck)
MMR+Varicella
residual
Twinrix (GSK)
Hep AB
≤2.5 mcg/mL
Vaqta (Merck)
Hep A
<0.1 mcg (Nonviral)
Zostavax (Merck)
Varicella Zoster
residual amounts
Serum, Fetal Bovine
Attenuvax (Merck)
Measles
<1 ppm
IPOL (sp)
Polio
<1 ppm
Meruvax II (Merck)
Rubella
<1 ppm
MMR II (Merck)
MMR
<1 ppm
Mumpsvax (Merck)
Mumps
<1 ppm
ProQuad (Merck)
MMR+varicella
0.5 mcg
RotaTeq (Merck)
Rotavirus
trace amounts
Varivax (Merck)
Varicella
trace amounts
Zostavax (Merck)
Varicella Zoster
trace amounts
Sodium Borate (Decahydrate)
Comvax (Merck)
Hib-HepB
35 mcg (0.035 mg)
Gardasil (Merck) HPV 35 mcg Vaqta (Merck) Hep A 35 mcg pediatric; 70 mcg in adult formulation Sodium Chloride
Afluria (CSL)
Influenza 4.1 mg
Attenuvax (Merck)
Measles
Cervarix (GSK)
HPV
4.4 mg
Comvax (Merck)
Hib-HepB
0.9%
Engerix-B (GSK)
Heb B
9 mg/mL
Fluarix (GSK)
Influenza
Fluzone (sp) Influenza Gardasil (Merck) HPV 9.56 mg
H1N1 (CSL)
H1N1 Influenza
4.1 mg
HibTITER (Wyeth)
Hib
dissolved in 0.9% sodium chloride
Infanrix (GSK)
DTaP
4.5 mg/mL (2.25 mg)
Meruvax II (Merck)
Rubella
MMR II (Merck)
MMR
Mumpsvax (Merck)
Mumps
Pediarix (GSK)
DTaP-HepB-IPV
4.5 mg
ProQuad (Merck)
MMR+Varicella
2.4 mg
Twinrix (GSK)
Heb AB
Typhim Vi (sp)
Typhoid
4.150 mg
Varivax (Merck)
Varicella
3.2 mgt
YF-Vax (sp)
Yellow Fever
0.6 mL in diluent
Zostavax (Merck)
Varicella Zoster
3.99 mg
Sodium Deoxycholate
Fluarix (GSK)
Influenza
≤ 50 mcg
FluLaval (GSK)
Influenza
≤ 50 mcg
H1N1 (CSL)
H1N1 Influenza
≤10 ppm Sodium Taurodeoxycholate
H1N1 (GSK)
H1N1 Influenza
≤50 mcg
Sodium Dihydrogen phosphate
Engerix-B (GSK)
Hep B
0.71 mg/mL
Cervarix (GSK)
HPV
0.624 mg
Sodium EDTA
RabAvert (Novartis)
Rabies
0.3 mg
Sodium Hydroxide
RotaTeq (Merck)
Rotavirus
Sodium Phosphate Afluria (CSL)
Influenza
300 mcg, Dibasic
80 mcg, Monobasic
Attenuvax (Merck)
Measles
H1N1 (CSL)
H1N1 Influenza
300 mcg, Dibasic
80 mcg, Monobasic
Engerix-B (GSK)
Hep B
0.98 mg/mL Disodium phosphate
Meruvax II (Merck)
Rubella
MMR II (Merck)
MMR
Mumpsvax (Merck)
Mumps
ProQuad (Merck)
MMR+Varicella
0.34 mg, dibasic
Rotarix (Merck)
Rotavirus
Varivax (Merck)
Varicella
0.45 mg
ProQuad (Merck)
MMR+Varicella
0.34 mg
RotaTeq (Merck) Rotavirus Monobasic Monohydrate
Typhim Vi
Typhois 0.065 mg Disodium Phosphate
0.023 mg Monosodium Phosphate
Varivax
Varicella 0.45 mg Sodium Phosphate Diabasic
trace amounts Sodium Phosphate Monobasic
Zostavax (Merck)
Varicella Zoster
0.57 mg Sodium Phosphate Dibasic
Sucrose
ActHIB (sp)
Hib
8.5%
Attenuvax (Merck)
Measles
1.9 mg
Fluarix (GSK)
Influenza
FluMist (Medimmune)
Influenza
13.68 mg/dose
Fluzone (sp)
Influenza
≤12%
H1N1 (CSL) H1N1 Influenza ≤ 2% H1N1 (sp) H1N1 Influenza ≤ 2% H1N1-nasal (MedImmune) H1N1 Influenza 13.68 mg/dose
Meruvax II (Merck)
Rubella
1.9 mg
MMR II (Merck)
MMR
1.9 mg
Mumpsvax (Merck)
Mumps
1.9 mg
ProQuad (Merck)
MMR+Varicella
≤ 21 mg
RotaTeq (Merck)
Rotavirus
Tripedia (sp)
DTaP
8.5%
Varivax (Merck)
Varicella
25 mg
Vivotif Bernal (Berna)
Typhoid
26-130 mg
Zostavax (Merck)
Varicella Zoster
31.16 mg
Sorbitol
Attenuvax (Merck)
Measles
14.5 mg
Meruvax II (Merck)
Rubella
14.5 mg
MMR II (Merck)
MMR
14.5 mg
Mumpsvax (Merck)
Mumps
14.5 mg
ProQuad (Merck)
MMR+Varicella
1.8 mg
Rotarix (Merck)
Rotavirus
YF Vax (sp)
Yellow Fever
as stabilizer
Thimerosal
Fluarix (GSK)
Influenza
trace amount ≤ 1 mcg mercury
FluLaval (GSK)
Influenza
25 mcg mercury
Fluvirin (Novartis)
Influenza
24.5 mcg
Fluzone (sp)
Influenza
none in No Preservative presentations; 25 mcg mercury in 0.5 mL prefilled and multi-dose syringe
JE-Vax (sp)
Japanese Encephalitis
0.007%
Pediarix (GSK)
DTaP-HepB-IPV
<12.5 ng mercury
Yeast
Comvax (Merck)
Hib-HepB
"The vaccine contains no detectable yeast DNA, and 1% or less of the protein is of yeast origin."
Engerix-B (GSK)
Hep B
<5% yeast protein
Gardasil (Merck) HPV <7 mcg yeast protein/dose HibTITER (Wyeth) Hib "…yeast extract-based medium that is ultrafiltered before use."
Menveo (Novartis)
Meningococcal
"...CY medium containing yeast extracts..."
Pediarix (GSK)
Hep B
≤5% yeast protein
Prevnar (WL)
Pneumococcal
"…and yeast extract-based medium"
Recombivax HB (Merck)
Hep B
<1%
Twinrix (GSK)
Hep AB
≤5% yeast protein
Vivotif Berna (Berna)
Typhoid
yeast extract from media
updated February 2010
This page was last updated on February 23, 2010
© 2010 Institute for Vaccine Safety
